Exome Sequencing Of Familial Atrial Fibrillation Informs Positive Treatment With Cannabidiol (CBD)



EXOME SEQUENCING OF FAMILIAL ATRIAL FIBRILLATION INFORMS POSITIVE TREATMENT WITH CANNABIDIOL.

9 Comments

  1. Hi Kevin, are there any doctors in the Los Angeles area (or anywhere in California) who will work with a patient with afib and fast heart rate using CBD oil so can be weaned off the pharma drugs?

  2. Hi Kevin, This is a VERY interesting video to me (age 64) because I was recently diagnosed with Atrial Fibrillation and was found to be VERY sensitive to the diltiazem and verapamil. Those two medications prescribed to stop the Afib put me into the emergency room three times with slow heart rate and long pauses. I bought the Kardia device from AliveCor and happened to also be on a month long monitor during the third event. RhythmStar actually called me up to tell me to go the ER because of the long pauses and slow heart rate. I was looking at my Kardia app on my phone at the time and was wondering about that. And that was a week after I have taken the last verapamil. Earlier before I had the Rhythmstar but when I did have the Kardia device and app I had someone drive me to the ER and was told my rate had gone as low as 38 BPM while in the ER and they had the crash cart nearby and the pads on me. Fortunately that was not needed. Each time I went the to ER they lowered the prescription. Now it is 30 mg diltiazem as needed with a second dose if the 1st does not stop the Afib (also on daily Eliquis). I did this was last week and it worked without putting me into the ER, but my at rest heart beat is still in the 50s. I have my 23 and Me results on Openhumans.org and would like to know more at this. You would think the drug maker and maybe my cardiologist would know which SNP variants would indicate who might be sensitive to these drugs and forecast a correct dosage so patients would not have to go to the very expensive ER. Both my parents had Afib events in their 60s and my mother had Pagets on her right foot. Please have someone contact me, I am very interested in learning more. You might also be interested in my variants. Best Regards, David Blackwell https://www.facebook.com/DCBlackwell dcblackwell at gmail dot com – PS in 2015 I had a bad sciatica attack, that prompted monthly B12 shots and it also forced me to go gluten free. Arhythmias also forced me to go caffeine free. I identified the SNP variants that probably caused high homocysteine and the sciatica. I have no damage to my spine so this is metabolic damage to my L5 myelin sheaths. I've done a fair amount of research on this at PubMed, but it is never enough.

  3. Pity; can't help the many people with potentially fatal allergy to cannabis. The allergy can actually cause fibrillation, tachycardia and present as a heart attack in severe cases;
     the opposite of what is wanted. People with cannabis allergy are also advised to avoid hemp seeds in health foods.

  4. Seth, its perhaps important to point out that it was a hemp oil which is oral mucosal and we avoided ones with peppermint (pro-arrhythmic) and paid close attention to grapefruit intake and pomegranate intake as these have DDI with CYP2C19 and CYP3A4/5

  5. 25mg, 3X daily (75kg patient)…but the supply was constantly changing on him due to CBD droughts post Sanjay Gupta CNN epilepsy story. The arrhthymias were sporadic so the patient never experienced use of CBD to reverse an event. Once on 1mg/kg they ceased to occur. Interestingly a year later his degen disk disease and joint pain is subsiding. He broke is back in his 3rd degree blackbelt test and has had several discs over the year degenerate. This may be related to the same calcium imbalance and this appears to be subsiding as well although at a slower pace. Recently papers on CBD and Degen Disc disease have published. http://www.medicinalgenomics.com/wp-content/uploads/2011/12/CBD_Degen_Disc.pdf

  6. Thank you so much for your medical-scientific contribution to this very important discussion… CBD for A fib… The cardiovascular implications are so huge (e.g. preventing/ameliorating atherosclerosis, hypertension, arrhythmia, CVA/MI, RPI, and thrombosis). Next, I would like to see some more research on the blood-thinning, stroke-preventing potential of cannabinoid-based therapies.

    It's interesting that, yes, smoking marijuana may increase some people's risk for having a heart attack, but what does that have to do with marijuana? Oh, that's right, you are smoking it. 

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